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专利名称：QUINOLINE DERIVATIVES AS
ANTIBACTERIAL AGENTS
发明人：ANDRIES, Koenraad J.L.M.,KOUL,
Anil,GUILLEMONT, Jérôme E.G.,LANÇOIS,David F.A.,MOTTE, Magali M.S.,DORANGE,Ismet,BACKX, Leo J.J.,MEERPOEL, Lieven
申请号：EP067638.0申请日：20060626公开号：EP114B1公开日：20120815
摘要：Use of a compound for the manufacture of a medicament for the treatment of abacterial infection provided that the bacterial infection is other than a Mycobacterialinfection, said compound being a compound of formula (Ia) or (Ib) a pharmaceuticallyacceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, atautomeric form thereof or a N-oxide form thereof, wherein R1 is hydrogen, halo,haloalkyl, cyano, hydroxy, Ar, Het, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl,Ar-alkyl or di(Ar)alkyl; p is 1, 2, 3 or 4; R2 is hydrogen, hydroxy, mercapto, alkyloxy,alkyloxyalkyloxy, alkylthio, mono or di(alkyl)amino or a radical of formula ; R3 is alkyl, Ar,Ar-alkyl, Het or Het-alkyl; q is 1, 2 or 3; R4 and R5 are hydrogen, alkyl or benzyl; or R4and R5 together and including the N to which they are attached may form a ring; R6 ishydrogen, halo, haloalkyl, hydroxy, Ar, alkyl, alkyloxy, alkylthio, alkyloxyalkyl,
alkylthioalkyl, Ar-alkyl or di(Ar)alkyl ; or two vicinal R6 radicals may be taken together toform a bivalent radical of formula - CH=CH-CH=CH-; r is 1, 2, 3, 4 or 5; R7 is hydrogen,
alkyl, Ar or Het; R8 is hydrogen or alkyl; R9 is oxo ; or R8 and R9 together form theradical -CH=CH-N=.
申请人：JANSSEN PHARMACEUTICA NV
地址：BE
国籍：BE
代理机构：Vervoort, Liesbeth
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