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专利名称：Antisense antibacterial cell division
composition and method
发明人：Patrick L. Iversen申请号：US09754468申请日：20010104公开号：US07049431B2公开日：20060523
专利附图：
摘要：Antisense oligomers directed to bacterial cell division and cell cycle-encodingnucleic acids are capable of selectively modulating the biological activity thereof, and areuseful in treatment and prevention of bacterial infection. The antisense oligomers are
substantially uncharged, and contain from 8 to 40 nucleotide subunits, including atargeting nucleic acid sequence at least 10 nucleotides in length which is effective tohybridize to (i) a bacterial tRNA or (ii) a target sequence, containing a translational startcodon, within a bacterial nucleic acid which encodes a protein associated with cell divisionor the cell cycle. Such proteins include zipA, sulA, secA, dicA, dicB, dicC, dicF, ftsA, ftsI,ftsN, ftsK, ftsL, ftsQ, ftsW, ftsZ, murC, murD, murE, murF, murG, minC, minD, minE, mraY,mraW, mraZ, seqA, ddlB, carbamate kinase, D-ala D-ala ligase, topoisomerase, alkylhydroperoxide reductase, thioredoxin reductase, dihydrofolate reductase, and cell wallenzyme.
申请人：Patrick L. Iversen
地址：Corvallis OR US
国籍：US
代理机构：Perkins Coie LLP
代理人：LeeAnn Gorthey
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